儿童特应性皮炎患者过敏原检测及氯雷他定联合他克莫司的疗效观察

目的检测儿童特应性皮炎的过敏原及观察氯雷他定联合他克莫司治疗儿童特应性皮炎的临床疗效。方法对78例特应性皮炎患儿采用BICOM生物共振体外过敏原检测系统检测过敏原；选用氯雷他定联合他克莫司治疗，并进行临床观察比较。结果特应性皮炎患儿过敏原检测中以食物组过敏原最常见（χ^2=6．24，P〈0．05）；食物组过敏原中以食品添加剂包括防腐剂、香精、香料、甜味剂、食用色素等所占比例最高，达42．4％，其次是鱼类、鸡蛋、牛奶等食物。氯雷他定联合他克莫司治疗儿童特应性皮炎效果明显。结论食品添加剂是儿童特应性皮炎主要的过敏原，氯雷他定联合他克莫司治疗儿童特应性皮炎有效。

Detection of allergen of children atopic dermatitis and the therapeutic effect of tacrolimus combined with loratadine in treatment

Objective To detect the allergens of children atopic dermatitis and the therapeutic effect of tacrolimus combined with loratadine in treatment. Methods BIOCM biology reso - nance system was used to detect allergens in 78 cases of atopic dermatitis, who were treated by tacrolimous combined with loratadine. Results The positive rate of allergen of allergic dermatitis was higher than that of asthma and allergic rhinitis, food was the most common allergen detected in atopic dermatitis （χ^2 = 6. 24, P 〈 0. 05 ） , in which food additive including preser - vative, essence, sweeteners and edible pigment accounted for the most proportion （42. 4% ）, fish, egg and milk etc were in the next place. It showed significant therapeutic effect in atopic dermatitis by combining tacrolimous and loratadine therapy. Conclusion Food additives are the most common allergens in atopic dermatitis. Combined tacrolimous and loratadine therapy is effective for children atopic dermatitis.