Intraoperative radiation therapy |
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Authors: | C G Willett |
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Institution: | (1) Department of Radiation Oncology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA Tel. +1-617-724-1548; Fax +1-617-726-3603 e-mail: cwillett@partners.org, US |
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Abstract: | The modern use of intraoperative radiation therapy (IORT) was initiated by the studies of Abe and colleagues at the University
of Kyoto. This work stimulated significant laboratory and clinical investigation into the use of IORT throughout Japan, Europe,
and the United States. Because of this experience, single high doses of irradiation can be safely delivered to a tumor volume
in appropriate clinical situations. Most importantly, this high dose of additional radiation treatment yields improved local
control of selected tumors. Treatment programs of external beam radiation therapy, surgical resection, and IORT for patients
with locally advanced primary and recurrent rectal carcinoma and retroperitoneal sarcoma have yielded excellent local control
and higher survival rates. The future of IORT will be in the successful integration of this therapy into multimodality treatment
programs of chemotherapy, external beam irradiation, and surgery for locally advanced malignancies.
Received: August 20, 2001 |
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Keywords: | Intraoperative radiation therapy Rectal cancer Retroperitoneal sarcoma |
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