The effect of adrenalectomy on morphine analgesia and tolerance development in rats |
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| Authors: | G F Gebhart C L Mitchell |
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| Affiliation: | 1. College of Hydropower & Information Engineering, Huazhong University of Science and Technology, Wuhan 430074, China;2. Department of Biological and Agricultural Engineering & Zachry Department of Civil & Environmental Engineering, Texas A&M University, College Station, TX 77843-2117, USA;3. National Water Center, UAE University, Al Ain, United Arab Emirates;1. School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, 830011, PR China;2. Clinical Laboratory Center, People’s Hospital of Xinjiang Uygur Autonomous Region Urumqi, Xinjiang, 830001, PR China;3. State Key Laboratory of Pathogenesis, Prevention, Treatment of Central Asian High Incidence Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830011, PR China;4. Department of Immunology, Basic Medical College of Xinjiang Medical University, Urumqi, Xinjiang, 830011, PR China;1. Business School, Sichuan University, Chengdu 610064, PR China;2. Decision Sciences Department, LeBow College of Business, Drexel University, Philadelphia, PA 19104, USA;3. Sichuan Institute of Building Research, Chengdu 610064, PR China |
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| Abstract: | The analgesic response to morphine and the development of tolerance to this effect were examined in adrenalectomized and sham-operated rats employing the hot plate method. In a quantitative 6 point bioassay procedure, morphine was found to be 1.8 times more efficacious in adrenalectomized rats. An analysis of variance of data collected in quantal fashion revealed a complementary relative efficacy of 1.7. The rates of tolerance development to the analgesic effect of morphine over the 5 day period of the experiment were found to be equivalent in both groups of rats at either of 2 equi-analgesic morphine dose levels employed. It was concluded that whereas the effect of adrenalectomy on the analgesic response to morphine is significant, it is insignificant with respect to the rate of tolerance development. |
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