| 强直性脊柱炎实验室诊断的研究进展 |
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| 引用本文： | 胡志东,王金良. 强直性脊柱炎实验室诊断的研究进展[J]. 医学综述, 2008, 14(11): 1678-1681 |
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| 作者姓名： | 胡志东 王金良 |
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| 作者单位： | 1. 天津医科大学总医院检验科,天津,300052
2. 天津公安医院检验科,天津,300051 |
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| 摘 要： | 强直性脊柱炎(AS)是临床常见的一种自身免疫性疾病。目前除了人类白细胞抗原B27,还没有找到其他更特异和敏感的实验室指标用于诊断AS。近几年来,随着人们对AS发病机制研究的进展,发现了几种细胞因子在AS发生、发展中起着重要作用。例如,肿瘤坏死因子α、Th亚群细胞因子、白细胞介素8、血管内皮生长因子、转化生长因子β1、基质金属蛋白酶3等。仅对AS实验室诊断进展予以概述。
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| 关 键 词： | 强直性脊柱炎 人类白细胞抗原B27 细胞因子 基质金属蛋白酶 |
| 文章编号： | 1006-2084(2008)11-1678-04 |
| 修稿时间： | 2007-04-22 |
Development of Laboratory Diagnosis of Ankylosing Spondylitis |
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| HU Zhi-dong,WANG Jin-liang. Development of Laboratory Diagnosis of Ankylosing Spondylitis[J]. Medical Recapitulate, 2008, 14(11): 1678-1681 |
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| Authors: | HU Zhi-dong WANG Jin-liang |
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| Affiliation: | HU Zhi-dong1,WANG Jin-liang2.(1.Department of Laboratory Medicine,General Hospital of Tianjin Medical University,Tianjin 300052,China,2.Department of Laboratory Medicine,Tianjin Gong'an Hospital,Tianjin 300051,China) |
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| Abstract: | Ankylosing spondylitis（AS）is a kind of autoimmune disease.At present,any other laboratory index with more specificity and sensitivity have not been found besides human leucocyte antigen-B27（HLA-B27）till now.With the further study about its pathogenesis,many cytokines were found to play an important role in the genesis and development of this disease,such as tumor necrosis factor α（TNF-α）,cytokines of Th cell,interleukin-8（IL-8）,vascular endothelial growth factor（VEGF）,tumor necrosis factor α（TGF-β1）,Matrix metalloproteinase-3（MMP-3）,and so on.This article reviews the progress of this disease about its laboratory diagnosis. |
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| Keywords: | Ankylosing spondylitis Human leucocyte antigen-B27 Cytokine Matrix metalloproteinase-3(MMP-3) |
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