See-saw nystagmus and brainstem infarction MRI finclings

A patient with see-saw nystagmus had a lesion localized by Magnetic Resonance Imaging (MRI) to the paramedian ventral midbrain with involvement of the right interstitial nucleus of Cajal. This is the first MRI study of see-saw nystagmus associated with a presumed brainstem vascular event. Our finclings support animal and human studies suggesting that dysfunction of the interstitial nucleus of Cajal or its connections is central in this disorder.