Metabolism in the rat of a model xenobiotic plant metabolite S-benzyl-N-malonyl-L-cysteine |
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Abstract: | 1. The metabolism of a model xenobiotic plant metabolite S-benzyl-N-malonyl-L-cysteine (BMC) administered to rat at 10?mg/kg has been studied using a combination of radio-t.l.c. and?h.p.l.c.2. The major route of excretion for the administered 14C was via the urine (79% in 3 days).3. The major metabolite was hippuric acid. The extent of biotransformation of BMC indicated the lability of the N-malonyl bond whose hydrolytic removal initiated a metabolic sequence which involved the action of C-S lyase to produce benzyl thiol.4. A comparison of the findings from this study with those from experiments with N-acetyl-S-benzyl-L-cysteine and S-benzyl-L-cysteine is made to support the metabolic pathway proposed. |
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