The Metabolism of Tinidazole in the Rat and Dog

Abstract

1. [³⁵S]Tinidazole was administered to dogs and rats by oral and intravenous routes. Methods for the determination of tinidazole and total nitroimidazoles are described.

2. The main route for excretion of radioactivity was the urine in both species.

3. In the dog the serum contained predominantly unchanged drug.

4. In both species unchanged drug accounted for about half the urinary radioactivity; the remaining radioactivity was due to four metabolites.

5. One metabolite is the product of hydroxylation of the 2-methyl group and another is its O-glucuronide. The other two metabolites have not been identified, but they do not appear to be simple nitroimidazoles.

6. It is concluded that the metabolic fate of tinidazole is similar in dogs and rats.