血清hs-CPR浓度和冠脉病变复杂程度的相关性

目的探讨冠心病患者血清超敏C反应蛋白(hs-CRP)水平与冠脉病变复杂程度的关系。方法对140例冠脉造影患者,按照冠脉造影下冠脉病变复杂程度将所有患者分为单支病变组(n=36)、双支病变组(n=41)、多支病变组(n=28)及对照组(n=35)采用免疫透射比浊法测患者血清的hs-CPR水平,根据冠脉造影结果行Gensini评分。结果血清hs-CRP和Gensini积分在不同冠脉病变组间差异有显著性,且随着病变血管支数增加而增高(P0.01)。血脂、hsCRP与Gensini积分呈显著正相关(r=0.314,P0.001),hsCRP是Gensini积分的独立影响因子。结论血清hs-CRP浓度与冠脉病变程度及危险因素有相关性,对冠心病患者的病变预测有较好的临床意义。

Relationship between high sensitivity C-reactive protein level and angiographical characteristics of coronary atherosclerosis

Objective To explore relationship between the level of serum high sensitivity C-reactive protein and severity of coronary artery. Methods The study concluded 140 consecutive patients and divided them into 1-vessel lesin group（ n = 36） ,2-vessel lesin group （n = 41 ） ,3-vessel lesin group（ n = 28 ）and control gruop（ n = 35 ）. The high sensitivity C-reactive protein level was measured by particle enhanced immunoturbidimetric assay. The severity of coronary atherosclerosis was defined by the Gensini＇ s score. Results The hs-CRP and Gensini score were different among the groups. As the number of diseased vessels increased, the differense increased. Gensini score was associated with lipid and hs-CRP, and hs-CPR was independently associated with the Gensini score. Conclusion The level of plasma hs-CRP was significantly associated with the severity of coronary atherosclerosis and useful for prediction of coronary lesions.