不同年龄发病的原发性干燥综合征的免疫学异常及临床特点的比较

目的探讨不同年龄发病的原发性干燥综合征患者实验室指标和临床特点的异同。方法回顾性分析136例不同年龄发病的原发性干燥综合征患者的临床及实验室资料。结果抗SSA及抗SSB抗体阳性率随发病年龄增高呈现下降趋势；≤45岁发病的干燥综合征患者血清类风湿因子滴度、循环免疫复合物水平显著高于中老年干燥综合征患者,而补体C3水平明显低于＞45岁发病组；≤45岁发病的干燥综合征患者的腮腺炎发生率显著＞45岁之后发病者；腺体外损害两组差异无统计学意义。结论与＞45岁发病的干燥综合征相比,≤45岁发病的干燥综合征患者免疫指标异常及腮腺受累更常见,提示青年发病干燥综合征患者体内有更强的免疫应答。

Comparisons of clinical characteristics of primary Sj(o)gren''s syndrome onset at different ages

Objective To study the difference in clinical characteristics and experimental profiles of primary Sj gren's syndrome(pSS)with a different onset age.Methods The clinical and laboratory data of 136 pSS patients were retrospectively analyzed.Results The prevalence of anti-SSA and anti-SSB antibodies de- clined with later onset.As compared with patients with disease onset older than 45,patients with disease onset younger than 45 had higher rheumatoid factor,circulating immune complex and lower C3.The prevalence of parotitis was higher in patients with disease onset younger than 45 than those with disease onset older than 45. The two groups had similar extra-glandular involvement.Conclusion The younger onset pSS patients have more abnomlalities in inmmnological parameters,and more parotiditis,implying that young onset pSS have more strong immune responses.