| 膀胱肿瘤中的遗传学改变 |
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| 引用本文： | 王一,孙光. 膀胱肿瘤中的遗传学改变[J]. 医学综述, 2009, 15(16): 2425-2427 |
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| 作者姓名： | 王一 孙光 |
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| 作者单位： | 天津市泌尿外科研究所,天津医科大学第二医院泌尿外科,天津,300211 |
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| 基金项目： | 天津市卫生局科技基金 |
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| 摘 要： | 新发现的癌基因及抑癌基因在膀胱肿瘤病因学中扮演着重要的角色,如p53、丝氨酸苏氨酸蛋白激酶15、三倍功能区、脆性三联组氨酸、p63基因、20号染色体长臂及5号染色体短臂基因突变、血管发生、基质重塑基因产物等。本文对膀胱肿瘤发生相关癌基因和抑癌基因予以综述。
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| 关 键 词： | 膀胱癌 基因 遗传学 |
Genetic Alterations in Urothelial Bladder Carcinoma |
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| WANG Yi,SUN Guang. Genetic Alterations in Urothelial Bladder Carcinoma[J]. Medical Recapitulate, 2009, 15(16): 2425-2427 |
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| Authors: | WANG Yi SUN Guang |
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| Affiliation: | WANG Yi, SUN Guang. (Department of Urology, Tianjin Institute of Urology,the Second Hospital of Tianjin Medical University, Tianjin 300211, China) |
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| Abstract: | The newly discovered oneogenes and tumor suppressor genes play an important role in the pathogenesis of urothelial bladder carcinoma, such as p53, serine threonine protein kinase 15 （STK15）, triple-function domain （ TRGIO）, fragile histidine triad （ FHIT ）, p63 genes, and alterations of 20q and 5 p, alterations of adhesions, angiogenesis, and matrix-remodeling gene products and others. This article reviewed the oneogenes and tumor suppressor genes involved in occurrence and development of urothelial carcinoma. |
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| Keywords: | Urothelial bladder carcinoma Gene Genetics |
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