草酸铂联合方案治疗晚期复治胃肠道癌的临床观察

目的：研究奥沙利铂(L-OHP)与氟尿嘧啶(5-Fu)、甲酰四氢叶酸钙(CF)联合方案治疗晚期并含5-Fu方案化疗失败的胃癌和大肠癌的疗效和毒副反应。方法：L-OHP 35mg／m^2，静脉滴注4h，d1～d4；5-FU 500mg／m^2，静脉滴注4h(接L-OHP)，d1～d4,CF 100mg／m^2，静脉滴注4h(5-Fu与CF从Y型管同时滴注)，d1～d4，21或28天为1周期。结果：共治疗22例患，CR1例，PR6例，SD8例，PD7例，有效率为31．8％。各病种的疗效为：胃癌2／4例，大肠癌27．8％(5／18)。中位有效缓解期为4个月(范围2～7个月)。有54．5％(12／22)患在治疗后原有的临床症状有不同程度的改善。主要不良反应为贫血、白细胞和血小板减少、恶心呕吐、口腔炎及末梢神经炎，多为1～2度。结论：奥沙利铂与5-Fu、CF联合应用治疗晚期、复治的胃肠道癌疗效确切，毒副反应能耐受．

Oxaliplatin combined with fluorouracil and calaium folinate in the treatment of patients with advanced and pretreated gastroinstestinal cancer

Objective:To study the response and toxicity of the regimen of oxaliplatin (L OHP) combined with fluorouracil(5 Fu) and calcium folinate(CF)in the treatment of advanced and pretreated gastrointestinal cancer Methods:22 cases with advanced,failed previous 5 Fu based chemotherapy gastrointestinal cancer (including 4 patients with gastric cancer and 18 patients with colorectal cancer)were treated with:L OHP 35mg/m 2 iv infusion for 4 h D1 to D4,followed by 5 Fu 500mg/m 2 for 4h D1 to D4,and CF 100mg/m 2 for 4h D1 to D4(5 Fu and CF were infused at the same time),repeated every 3 or 4 weeks Results:The total response rate was 31 8%,the main side effects were bone marrow suppression,nausea and vomiting,oral mucositis and peripheral sensory neuropathy.The whole toxicity was mild and tolerable Conclusion:The regimen of L OHP combined with 5 Fu/CF was effective and well tolerable in the treament of patients with advanced and pretreated gastrointestinal cancer