Mycoplasmacidal Activity of Peroxidase-H2O2-Halide Systems |
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| Authors: | A A Jacobs I E Low B B Paul R R Strauss and A J Sbarra |
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| Institution: | aDepartment of Pathology and Medical Research, St. Margaret''s Hospital, Department of Obstetrics and Gynecology, Tufts University School of Medicine, and Department of Bacteriology, Harvard University School of Medicine, Boston, Massachusetts 02125 |
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| Abstract: | A mycoplasmacidal system consisting of myeloperoxidase (MPO)-containing granules, H(2)O(2), and a halide is described. In all parameters measured, it appears to be identical to the MPO-H(2)O(2)-halide bactericidal system previously reported. It has a pH optimum of approximately 5.5 and an optimal MPO:H(2)O(2) ratio of 1:25. The halide requirement can be satisfied by either chloride or iodide. Through the use of taurine or horseradish peroxidase substitution, chloride-mediated killing can be distinguished from iodide-mediated killing. The relationship of this mycoplasmacidal system to other mycoplasmacidal systems and to host surveillance of mycoplasma is discussed. |
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