Proteinase-activated receptor 2-mediated calcium signaling in hepatocellular carcinoma cells |
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| Authors: | Roland Kaufmann Franziska Mußbach Petra Henklein Utz Settmacher |
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| Institution: | 1.Department of General, Visceral and Vascular Surgery,Medical Faculty at the Friedrich Schiller University Jena,Jena,Germany;2.Institute of Biochemistry, Charité,Humboldt University of Berlin,Berlin,Germany;3.Experimental Transplantation Surgery, Department of General, Visceral and Vascular Surgery,Medical Faculty at the Friedrich Schiller University Jena,Jena,Germany |
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| Abstract: | Purpose The proteinase-activated receptor-2 (PAR2), a member of a newly discovered G protein–coupled receptor subfamily has recently been shown to promote hepatocellular carcinoma
(HCC) cell invasion, suggesting a function in HCC progression. In this study, the effect of PAR2 on intracellular calcium and its involvement in p42/p44 MAPKinase activation in HEP-3B cells and in two primary HCC cultures
established from surgically resected HCC specimens has been investigated. |
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