Clinical case of cerebral amebiasis caused by E. histolytica |
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Authors: | Maldonado-Barrera Cinthya A Campos-Esparza Maria Del Rosario Muñoz-Fernández Luis Victoria-Hernández Joaquin A Campos-Rodríguez Rafael Talamás-Rohana Patricia Ventura-Juárez Javier |
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Institution: | (1) Departamento de Morfolog?a, Centro de Ciencias B?sicas, Universidad Aut?noma de Aguascalientes, Av Universidad 940, Col. Cd. Universitaria, Aguascalientes, CP. 20131, Mexico;(2) Departamento de Patolog?a, Centenario Hospital Miguel Hidalgo, Aguascalientes, Mexico;(3) Departamento de Bioqu?mica, ESM-IPN, M?xico City, Mexico;(4) Departamento de Infect?mica y Patog?nesis Molecular, CINVESTAV-IPN, M?xico City, Mexico; |
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Abstract: | Although amebic brain abscess is a rare form of invasive amebiasis, when present, it is frequently lethal. This disorder always
begins with the infection of the colon by Entamoeba histolytica trophozoites, which then travel to extra-intestinal tissues through the bloodstream. Amebic brain abscesses are produced
when trophozoites invade the central nervous system. Computerized axial tomography scans can be used to diagnose the presence
or absence of a brain abscess with a certainty of 100%. However, this diagnostic tool does not reveal the etiological agent
of disease. By analyzing the clinical case of a patient that died due to untimely treatment of this malady, the present study
aims to identify a diagnostic tool that can give a precise determination of the etiological agent and therefore permit adequate
and opportune treatment. Currently, diagnosis of amebic brain abscess is often done by identification of the ameba in a biopsy
or autopsy. By immunohistochemistry and immunofluorescence with specific antibodies, we identified the existence of E. histolytica, which presents proteins similar to Naegleria fowleri in its membrane. |
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