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Oral insulin stimulates intestinal epithelial cell turnover following massive small bowel resection in a rat and a cell culture model |
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| Authors: | Shani Ben Lulu Arnold G. Coran Naim Shehadeh Raanan Shamir Jorge G. Mogilner Igor Sukhotnik |
| Affiliation: | (1) The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Laboratory of intestinal adaptation and recovery, Haifa, Israel;(2) Department of Pediatric Surgery B, Bnai Zion Medical Center, 47 Golomb St, P.O.B. 4940, Haifa, 31048, Israel;(3) Department of Pediatrics, Meyer Children’s Hospital, Rambam Medical Center, Haifa, Israel;(4) Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children’s Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel;(5) Section of Pediatric Surgery, C.S. Mott Children’s Hospital and University of Michigan Medical School, Ann Arbor, MI, USA; |
| Abstract: | PurposeWe have recently reported that oral insulin (OI) stimulates intestinal adaptation after bowel resection and that OI enhances enterocyte turnover in correlation with insulin receptor expression along the villus–crypt axis. The purpose of the present study was to evaluate the effect of OI on intestinal epithelial cell proliferation and apoptosis in a rat model of short bowel syndrome (SBS) and in a cell culture model. |
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