高原急性缺氧对大鼠心肌结构的影响

为明确早期高原实地缺氧对大鼠心肌结构的影响 ,对携至不同海拔高原地区大鼠心肌组织的光、电镜标本进行了观察。结果 :光镜下大鼠各室壁心肌细胞均可见不同程度的浊肿、空泡变性、溶解坏死及间质水肿等 ;电镜下可见心肌细胞线粒体肿胀 ,肌浆网扩张 ,肌原纤维溶解 ,细胞内外水肿等 ,上述改变右室壁较左室壁明显 (P <0 .0 1 )。结果提示 :高原急性缺氧造成大鼠以右心室为主的全心性损伤 ,应重视高原缺氧早期的全心性防护。

Effect of Acute Hypoxia High Altitudeon Myocardical Structure in Rat

In order to determine the changes of the myocardial structure at the acute high altitude exposure in rats, the rats were took from lower to higher altitudes, the observation was aimed in the study of rat myocardial specimen under light and electronic microscopes. It was found that there were severe lesions in left and right ventricle and interventricular septum, such as cloud swelling, hydropic degeneration, lytic necrosis and interstitial edema under light microscope. The chondriosomes swelling, sarcoplasmic reticula dilatation, myofibrillae solution and edema of inside and outside of the celles were shown under electronic microscope. The lesions above were more severe in the right ventricle than those in the left(P< 0.01). The results revealed that the cardiac lesions of rats were pancardiac disribution obviously and the lesions of the right ventricle was more severe than those of the left ventricle. It′s also suggested that the protection of whole heart should be paid attention to when move to high altitude in short time.