基于整合药理学平台研究葛根芩连汤治疗小儿肺炎的作用机制

目的 基于整合药理学平台探索葛根芩连汤治疗小儿肺炎的作用机制。方法 本研究通过中药整合药理学平台,通过输入葛根、黄芩、黄连、甘草四味药及肺炎获取药物和疾病靶标,然后进行蛋白质-蛋白质相互作用及网络构建,进一步进行基因功能和通路富集分析,进行葛根芩连汤治疗肺炎的"中药-成分-靶标-通路"多维网络分析。结果 药物作用于疾病的关键通路包括细胞生长和死亡、传染病、细胞凋亡、免疫系统、趋化因子信号通路、B细胞受体信号通路、T细胞受体信号通路、血小板活化、胃酸分泌等。药物潜在靶标为GCK、COX7C、ATP1A1、ADCY2。结论 葛根芩连汤治疗小儿肺炎的机制可能通过与能量代谢及消化系统相关物质唾液等相关,推测其具有潜在的关系。

Mechanism of Gegen Qinlian Decoction in treating pediatric pneumonia based on integrated pharmacology platform

Objective To explore the mechanism of Gegen Qinlian Decoction in the treatment of children with pneumonia, and to find out the path and target of Gegen Qinlian Decoction in the treatment of children with pneumonia. Methods Through the integrated pharmacology platform of traditional Chinese medicine, the drug and disease targets were obtained by inputting puerarin, jaundice, berberine, licorice and pneumonia, and then protein-protein interaction and network construction were carried out to further carry out gene function and pathway enrichment. analysis. Results Key pathways for drug action in disease including cell growth and death, infectious diseases, apoptosis, immune system, chemokine signaling pathway, B cell receptor signaling pathway, T cell receptor signaling pathway, platelet activation, gastric acid Secretion and so on. Potential drug targets are GCK, COX7C, ATP1A1, and ADCY2. Conclusion The mechanism of Gegen Qinlian Decoction in the treatment of children with pneumonia may be presumed to have a potential relationship through the relationship with energy metabolism and salivary system related substances