基于定量CT分析血糖、血脂、腹部脂肪与骨密度的关系

目的采用定量CT(QCT)探讨血糖、血脂及腹部脂肪与骨密度(BMD)的关系。方法选取行低剂量胸部CT联合QCT检查的健康体检者1161名, 其中男752名, 女409名, 根据年龄分为20~、30~、40~、50~、60~、70~岁6个年龄段。空腹采集受检者静脉血, 检测血糖、总胆固醇(TC)、三酰甘油(TG)。采用QCT测量L₂中心水平层面腹部总脂肪(TAT)、腹内脂肪(VAT)、皮下脂肪(SAT)及腰椎BMD。结果男性不同年龄段组血糖、TC、TG、VAT、SAT、BMD间差异均有统计学意义(P < 0.05~P < 0.01), 女性不同年龄段组血糖、TC、TG、TAT、VAT、SAT、BMD间差异均有统计学意义(P < 0.01)。男性血糖、TC、TG、VAT、SAT与BMD均呈负相关关系(P < 0.05~P < 0.01), 女性血糖、TC、TG、TAT、VAT、SAT与BMD均呈负相关关系(P < 0.01)。多元线性回归分析显示, 血糖、VAT均为男性BMD的独立影响因素(P < 0.05和P < 0.01);TC、VAT均为女性BMD的独立影响因素(P < 0.01)。结论血糖可能是男性BMD的负性影响因素, TC可能是女性BMD的负性影响因素, 而VAT对不同性别BMD均有负性影响。

Study on the relationship between the blood glucose,blood lipid,abdominal fat,and bone mineral density based on the quantitative CT

ObjectiveTo explore the relationship between the blood glucose, blood lipids, abdominal fat, and bone mineral density(BMD) using quantitative computed tomography(QCT).MethodsA total of 1161 healthy subjects(including 752 males and 409 females) detected by low-dose chest CT combined with QCT were selected, and divided into the 20-29, 30-39, 40-49, 50-59, 60-69 and ≥70 years old six age groups.The venous blood of all subjects were collected on an empty stomach for detecting the levels of blood glucose, total cholesterol(TC) and triglyceride(TG).The QCT was used to measure the total adipose tissue(TAT), visceral adipose tissue(VAT), subcutaneous adipose tissue(SAT) and lumbar BMD at the central level of L₂.ResultsThe differences of the levels of blood glucose, TC, TG, VAT, SAT and BMD among different age groups in male were statistically significant(P < 0.05 to P < 0.01), and the differences of which among different age groups in female were statistically significant(P < 0.01).The levels of the blood glucose, TC, TG, VAT and SAT were negatively correlatied with BMD in male(P < 0.05 to P < 0.01), and the levels of blood glucose, TC, TG, TAT, VAT and SAT were negatively correlated with BMD in female(P < 0.01).The results of multiple linear regression analysis showed that the blood glucose and VAT were the independent influencing factors of male BMD(P < 0.05 and P < 0.01), and the levels of TC and VAT were the independent influencing factors of female BMD(P < 0.01).ConclusionsThe blood glucose may be a negative influencing factor of male BMD, the TC may be a negative influencing factor of female BMD, and the VAT has a negative effect on BMD of different genders.