抗单纯疱疹病毒活性的海洋化合物研究进展

单纯疱疹病毒(herpes simplex virus, HSV)是全球高度流行的病原体。目前核苷类似物如阿昔洛韦被用于单纯疱疹病毒的治疗,尽管其具有安全性和有效性,但这些药物的广泛使用导致耐药病毒株的出现,尤其是对于免疫功能低下的患者。为了解决这些问题,已有来自海洋的活性物质作为抗HSV药物的报道,且人们对海洋生物如藻类,海绵,被囊类动物,棘皮动物,软体动物,细菌以及真菌等作为抗HSV药物的来源产生了更大的兴趣。本综述重点介绍和总结了作为潜在抗HSV药物最有希望的海洋生物提取物,组分等, 以期为新型抗HSV药物的研发提供参考。

Research Advances in Marine Compounds with Anti-Herpes Simplex Virus Activity

Herpes simplex virus (HSV) is a highly prevalent pathogen in the world. The current treatments for HSV infections are nucleoside analogs such as acyclovir. Despite the safety and efficacy, extensive clinical use of these drugs has led to the emergence of resistant viral strains, especially in immunocompromised patients. To counteract these problems, alternative anti-HSV agents from marine derived natural products have been reported. Recently, there has been a great deal of interest regarding marine organisms such as algae, sponges, tunicates, echinoderms, mollusks, shrimp, bacteria, and fungus as promising anti-HSV agents. This review highlights and summarizes the most promising marine biological extracts and components as potential anti-HSV drugs, so as to provide reference for the development of novel anti-HSV drugs. .