| 有机磷解毒剂的研究2.吡啶甲醛肟碘甲烷盐(简称2-PAM)的药理作用 |
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| 引用本文： | 邵以德,王珏英,易鸿匹. 有机磷解毒剂的研究2.吡啶甲醛肟碘甲烷盐(简称2-PAM)的药理作用[J]. 药学学报, 1965, 12(6): 373-380 |
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| 作者姓名： | 邵以德 王珏英 易鸿匹 |
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| 作者单位： | 上海第一医学院药学系医学基础教研组，上海第一医学院药学系医学基础教研组，上海第一医学院药学系医学基础教研组 |
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| 摘 要： | 2-吡啶甲醛肟碘甲烷盐(2-PAM)为有效的有机磷解毒剂,本文对其药理作用作了初步的观察.证明对乌拉坦麻醉猫在接近临床用量时已能产生拟肾上腺素作用.连续应用多次后出现快速耐受现象.在应用抗肾上腺素药、利血平或切除两侧肾上腺后,2-PAM作用即减弱.C6即使用至50毫克/公斤,亦不能阻断其作用,而5毫克/公斤的阿托品几能完全取消之.对离体及在位蟾蜍心脏也表现兴奋,此作用可部分地被C6所阻断.2-PAM对离体豚鼠肠的兴奋作用,亦可被阿托品所取消.文内对其作用机制作了初步分析.
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| 收稿时间： | 1964-08-17 |
STUDIES ON ANTIDOTES AGAINST ORGANOPHOSPHORUS POISONING——A PRELIMINARY REPORT ON THE PHARMACOLOGY OF PYRIDINE-2-ALDOXINE METHIODIDE(2-PAM) |
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| SHAW IH-TEH WANG CHUI-YING IH HONG-PIH. STUDIES ON ANTIDOTES AGAINST ORGANOPHOSPHORUS POISONING——A PRELIMINARY REPORT ON THE PHARMACOLOGY OF PYRIDINE-2-ALDOXINE METHIODIDE(2-PAM)[J]. Acta pharmaceutica Sinica, 1965, 12(6): 373-380 |
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| Authors: | SHAW IH-TEH WANG CHUI-YING IH HONG-PIH |
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| Abstract: | The value of pyridine-2-aldoxine methiodide (2-PAM) as an antidote for organo- phosphorus poisoning has been well established. Here we intend to get an insight into some of its pharmacological actions other than its cholinesterase reactivating activity. In urethane anaesthetized cats, it caused excitation of respiration, elevation of blood pres- sure, contraction of nictitating membrane, and inhibition of intestinal movement. These effects were gradually weakened on repeated administration of the drug at short intervals and were much reduced or even abolished by bilateral adrenalectomy, pretreatment with tolazoline, reserpine, or large doses of atropine but not with C6. Besides, it stimulated the toad-heart and excited isolated guinea-pig ileum. The mechanism of its action was briefly discussed. |
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