CpG-寡核苷酸与支气管哮喘

Th1／Th2失衡是支气管哮喘的重要免疫学发病机制，近年在支气管哮喘的发病机制中取得较大进展，CD4^＋T辅助细胞按其分泌的细胞因子不同分为Th1和Th2细胞，Th1反应可以抑制Th2反应，抑制气遭慢性炎症，含有未甲基化CpG结构的寡核苷酸是近年研究较多的一种调节Th1／Th2平衡的免疫制剂，本文就其调节Th1／Th2平衡在支气管哮喘治疗中的应用前景作一综述。

CpG Oligodeoxynucleotides and asthma

Asthma is associated with the Th1/Th2 response imbalance,skewing of immune responses towards a Th2 phenotype,and resulting in eosinophilic inflammation,airway hyperresponsiveness and airway remodeling.Recent epidemiological studies suggest that reduced early-life exposure to strong Th1 stimuli in industrialized counties has skewed the Th1/Th2 balance towards Th2 responses.Recent studies also show that Oligodeoxynucleotides(ODN) containing sequence motifs centered on unmethylated CG dinucleotides(CpG-ODN) are immunostimulatory.CpG-ODN can suppress Th2-mediated eosinophilic inflammation,airway hyperresponsiveness and airway remodeling in murine asthma.CpG ODN may be an effective immunomodulatory agent in the treatment,and possibly prevention,of asthma.