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肠道黏膜M细胞与微生物相互作用机制研究进展
引用本文:许相洋,陈文标,丁小明,王育斌,陈昌欣. 肠道黏膜M细胞与微生物相互作用机制研究进展[J]. 胃肠病学和肝病学杂志, 2011, 20(8): 782-784
作者姓名:许相洋  陈文标  丁小明  王育斌  陈昌欣
作者单位:1. 泉州医学高等专科学校基础医学部,福建,泉州,362011
2. 泉州市第一医院消化内科
摘    要:M细胞是黏膜免疫系统中一种特化的抗原转运细胞,能将抗原由肠腔转运到上皮下的淋巴组织,从而诱导免疫黏膜免疫应答或免疫耐受。因此M细胞被认为是启动黏膜免疫应答的"门户",同时也为许多病原微生物的入侵提供突破口。研究M细胞摄取抗原的机制能为口服疫苗的设计开发提供更有效的途径。本文主要对M细胞的结构功能、M细胞摄取微生物抗原机制等方面作一简要综述。

关 键 词:黏膜免疫系统  M细胞  微生物

Progress of the interaction mechanisms about M cells and microorganism in the intestinal mucosa
XU Xiangyang,CHEN Wenbiao,DING Xiaoming,WANG Yubin,CHEN Changxin. Progress of the interaction mechanisms about M cells and microorganism in the intestinal mucosa[J]. Chinese Journal of Gastroenterology and Hepatology, 2011, 20(8): 782-784
Authors:XU Xiangyang  CHEN Wenbiao  DING Xiaoming  WANG Yubin  CHEN Changxin
Affiliation:XU Xiangyang1,CHEN Wenbiao1,DING Xiaoming1,WANG Yubin2,CHEN Changxin2 1.Department of Basic Medicine,Quanzhou Medical College,Quanzhou 362011,2.Department of Gastroenterology,First Hospital of Quanzhou,China
Abstract:M-cells are specialized cells found in the mucosal immune system.M-cells play important roles in transport of antigen from the lumen of the small intestine to mucosal lymphoid tissues,where processing and initiation of immune responses occur or immunological tolerance.Thus,M-cells act as gateways to the mucosal immune system and this function has been exploited by many invading pathogens.Understanding the mechanism by which M-cells sample antigen will provide a more effective way for the development of M-ce...
Keywords:The mucosal immune system  M-cells  Microorganism  
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