高压氧早期治疗脑梗死的临床疗效观察

目的 探讨高压氧（HBO）在脑梗死早期治疗中的临床疗效。方法 将104例发病6h以内的脑梗死患者随机分为治疗组和对照组。治疗组患者于巴曲酶快速静脉滴注后即给予HBO治疗，对照组于用药（巴曲酶）7d后才开始HBO治疗；HBO治疗每日1次，共治疗10次。治疗结束后对所有患者进行神经功能缺损评分（N1S），并通过MRI测定、比较各组患者的脑梗死灶最大截面积。结果 2组患者N1S评分均较治疗前明显下降（P〈0．01），而且治疗组疗效明显优于对照组（P〈0.05），其梗死灶最大截面积亦显著小于对照组（P〈0．01）。结论 对早期脑梗死患者联合应用药物及HBO治疗，可有效促进其神经细胞功能恢复，缩小梗死灶体积。

The efficacy of hyperbaric oxygen with patients with early stage cerebral infarction

Objective To evaluate the therapeutic efficacy of hyperbaric oxygen for patients with early stage cerebral infarction.Methods One hundred and four patients with early stage cerebral infarction(within 6 hours) were divided randomly into experimental and control groups.Hyperbaric oxygen(HBO)therapy was administrated immediately after batroxobin had been dripped quickly into the experimental group.HBO was initiated after the same drug was used for 7 days in the control group.HBO was administered once a day,10 times in all.Neurological im- pairment was scored and cerebral infarction areas were determined through MRI in all patients after the HBO therapy had been completed.Results The neurological impairment scores(NIS)were significantly lower after therapy than before therapy in each group,and lower in the experimental group than in the control group.Cerebral infarction areas in the experimental group were smaller than those of the control group.Conclusion HBO can encourage neurocyte function recovery and limit cerebral infarction areas in the early stage of cerebral infarction.