| 几种中草药及绿茶对B(a)P和NNK的抗诱变作用 |
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| 引用本文： | 张春玲,胡俊峰,曲江斌,袁晓燕.几种中草药及绿茶对B(a)P和NNK的抗诱变作用[J].癌变．畸变．突变,2003,15(2):101-103. |
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| 作者姓名： | 张春玲 胡俊峰 曲江斌 袁晓燕 |
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| 作者单位： | 山东大学公共卫生学院劳动卫生教研室,山东,济南,250012 |
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| 摘 要： | 目的: 探讨绿茶、茶多酚、半枝莲、白花蛇舌草及犀黄丸等的水溶性提取物对苯并芘B(a)P]和4-甲基亚硝胺基-1-(3-吡啶基)-1-丁酮(NNK)的抗诱变作用. 方法: 采用沙门氏菌回变试验(Ames试验). 结果: 除各受试物的最小剂量组外,其它浓度的绿茶、茶多酚、半枝莲、白花蛇舌草及犀黄丸等均具有明显的抑制B(a)P和NNK诱发TA 98和TA 100回复突变的作用.经统计学处理,各试验组与对照组比较有显著性差异(P<0.01). 结论: 受试的中草药和绿茶对B(a)P和NNK均有抗突变作用,且存在剂量反应关系.
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| 关 键 词： | 抗诱变作用 中草药 绿茶 苯并芘 4－甲基亚硝胺基－1－（3－吡啶基）－1－丁酮 |
| 文章编号： | 1004-616X(2003)02-0101-03 |
| 修稿时间： | 2002年7月29日 |
STUDY ON ANTIMUTAGENICITY OF CHINESE HERBAL MEDICINE AND GREEN TEA TO BENZOAPYRENE AND NNK |
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| Abstract: | Purpose: To investigate the antimutagenicity of water extract of green tea, tea polyphenol, Scutellaria barbata D. Don, Hedyotis diffusa wildi and Xihuangwan to benzoapyrene and 4_methylnitrosamino_1_(3_pyridy)_1_butanone(NNK). Methods: The A mes test was used in this study. Results: Except the lowest dosage group, all the other dosage groups of green tea, te a polyphenol, Scutellaria barbate,Hedyotis diffusa wildi and Xihua ngwan inhibited the reverse mutation of TA 98 and TA 100 induc ed by B(a)P and NNK significantly(P<0.01). Conclusion: The teste d Chinese herbal medicines and green tea have antimutagenicity to B(a)P and NNK, and there is a dose_effect relationship. |
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| Keywords: | antimetagenicity chinese herbal medicine green tea B(a)P NNK |
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