| 大籽獐牙菜化学成分研究 |
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| 引用本文： | 张媛媛,管棣,谢青兰,曹厚平. 大籽獐牙菜化学成分研究[J]. 中国药学杂志, 2007, 42(17): 1299-1300 |
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| 作者姓名： | 张媛媛 管棣 谢青兰 曹厚平 |
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| 作者单位： | 西南交通大学生物工程系,成都,610031 |
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| 摘 要： | 目的研究藏药大籽獐牙菜(Swertia macrosperma C.B.Clark)的化学成分。方法采用硅胶柱色谱进行分离纯化,根据化合物的理化性质和波谱解析鉴定其化学结构。结果从大籽獐牙菜的脂溶性部分分离得到6个化合物,分别鉴定为1,8-二羟基-3,5-二甲氧基酮(swerchirin,Ⅰ)、1-羟基-3,5-二甲氧基酮(Ⅱ)、1,8-二羟基-3,7-二甲氧基酮(methylswertianin,Ⅲ)、1-羟基-3,7,8-三甲氧基酮(decussatin,Ⅳ),齐墩果酸(oleanolic acid,Ⅴ)和1,5,8-三羟基-3-甲氧基酮(bellidifodin,Ⅵ)。结论化合物Ⅰ～Ⅴ均为首次从该植物中分离得到。
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| 关 键 词： | 大籽獐牙菜 龙胆科 酮 三萜酸 |
| 文章编号： | 1001-2494（2007）17-1299-03 |
| 收稿时间： | 2006-07-08; |
| 修稿时间： | 2006-07-08 |
Studies on Chemical Constituents of Swertia macrosperma |
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| ZHANG Yuan-yuan,GUAN Di,XIE Qing-lan,CAO Hou-ping. Studies on Chemical Constituents of Swertia macrosperma[J]. Chinese Pharmaceutical Journal, 2007, 42(17): 1299-1300 |
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| Authors: | ZHANG Yuan-yuan GUAN Di XIE Qing-lan CAO Hou-ping |
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| Affiliation: | Department of Biological Engineering, Southwest Jiaotong University, Chengdu 610031, China |
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| Abstract: | OBJECTIVE To study the chemical constituents of Tibetan drug,Swertia macrosperma C.B.Clark.METHODS The constituents were isolated on silica gel column chromatography and their structures were identified on the basis of physiochemical properties and spectral analysis.RESULTS Six compounds were isolated and identified as 1,8-dihydroxyl-3,5-dimethoxyxanthone(swerchirin,Ⅰ),1-hydroxyl-3,5-dimethoxyxanthone(Ⅱ),1,8-dihydroxyl-3,7-dimethoxyxanthone(methylswertianin,Ⅲ),1-hydroxyl-3,7,8-trimeth-oxyxanthone(decussatin,Ⅳ),oleanolic acid(Ⅴ)and 1,5,8-trihydroxyl-3-methoxyxanthone(bellidifodin,Ⅵ),respectively.CONCLUSION Compound Ⅰ～Ⅴ were obtained from this plant for the first time. |
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| Keywords: | Swertia macrosperma C.B.Clark gentianaceae xanthone triterpenoic acid |
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