脓毒性脑病患儿血清神经元特异性烯醇酶及S100B蛋白的表达及其临床意义

目的探讨脓毒性脑病（SAE）患儿血清脑损伤早期标志物神经元特异性烯醇酶（NSE）及S100B蛋白的表达，为临床早期诊断SAE及干预该病进展提供佐证。方法选择36例SAE为研究对象，依据脓毒性脑病诊断标准分为早期和晚期病例，同时选择20例健康儿童为对照组。检测血清NSE及S100B蛋白水平，分析两组血清NSE及S100B蛋白水平之间的差异，并与健康对照组进行比较。结果两期SAE血清NSE及S100B蛋白浓度明显高于对照组（P〈0．01），而且两期SAE之间存在显著性差异。早期和晚期SAE患儿进行改良GCS评分后，评分≤7的病例，其NSE和S100B蛋白增高水平无显著性差异。结论SAE患儿血清中脑损伤标志物NSE及S100B蛋白异常表达，早期监测NSE和S100B蛋白的异常表达对判断病情及预后有积极意义。

Change and Significance of Serum Neuron-Specific Enolase and S100B Protein in Children with Septic Encephalopathy

Objective To investigate the expression and clinical significance of serum markers of early brain injury ,neuron-specific enolase（NSE） and S100B protein in children with septic eneephalopathy（SAE）. Methods According to the diagnostic criteria of SAE,36 cases with SAE were divided into two groups with cases in early stage and ones in late stage, and 20 healthy children were selected as control group at the same time. Serum NSE and S100B protein levels were detected,and the differences of NSE and S100B protein between the two groups were analyzed. Results The levels of NSE and S-100B in the two groups with SAE were obviously higher than those in control group（P 〈 0.01 ）, and there were significant differences in serum concentrations of NSE and S-100B between the two groups. Conclusion There is significant increase of serum neuronspecific enolase and S100B protein in children with septic encephalopathy,which may be useful for early diagnosis and intervention of the disease.