与早产儿肺透明膜病相关的发病因素分析

[目的 ]　分析与早产儿肺透明膜病 (以下简称HMD)发病相关的诸因素 ,探讨预防的措施。 [方法 ]　对早产儿HMD患者 5 9例 ,就其出生体重、胎龄、分娩方式、阿氏评分和产前激素治疗等情况与HMD的相关性进行分析。[结果 ]　HMD的发病主要在胎龄 <32周、出生体重 <16 0 0克的早产儿 ;与分娩方式无明显相关 ;孕期有促胎肺成熟治疗者其存活率明显高于未进行激素治疗者 ;2 / 3的HMD患儿生后即有呼吸启动困难或窒息。 [结论 ]　加强孕期管理 ,预防早产是关键 ;对于难免早产者应积极进行促胎肺成熟治疗 ,争取保胎至孕周 >32周或出生体重超越 16 0 0克 ;分娩方式视母婴情况而定

Clinical analysis on factors related with hyaline membrane disease of the premature

Objective] To study the factors related with premature's hyaline membrane disease (HMD) and to inquire into the effective preventive measures. [Methods] 59 premature HMD cases were analysed in terms of the coherence between HMD and delivery method, birth weight, gestational age and Apgar score. The effect of fetal lung maturating therapy was studied. [Results] Delivery method was not coherent with HMD. The prematures with gestational age <32 weeks and/or birth weight <1600g were of high risk of HMD. The survival rate of the premature with fetal lung maturating therapy during gestation period was higher than that of the premature without such treatment. After birth, 2/3 premature HMD patients were difficult to start self-respiration or had asphyxia. [Conclusions] Prevention from HMD should be prior to cure of HMD. The key is to enhance gestation monitoring to avoid preterm labour. Fetal lung maturating therapy should be given to the pregnant if preterm delivery can not be avoided. Effort should be given to let the fetal be born under favourable conditions ie. gestational age >32 weeks or birth weight >1600g. Properly select delivery method according to the status of the pregnent and the fetus.