Refractory sprue |
| |
Authors: | Andrea N Culliford Peter H R Green |
| |
Institution: | (1) Division of Digestive and Liver Diseases, Columbia University College of Physicians and Surgeons, 161 Fort Washington Avenue, Suite 645, 10032 New York, NY, USA |
| |
Abstract: | Celiac disease is a T cell-mediated disorder that results from intolerance to gluten. The major cause of failure to respond
to a gluten-free diet is continuing gluten ingestion. In poorly responsive patients diagnosis of refractory sprue can be established
after exclusion of a limited number of conditions. Refractory sprue may occur after an initial response to the diet or without
evidence of preexisting celiac disease. The detection of aberrant, clonally expanded, intraepithelial lymphocytes has led
to better definition and classification of patients with refractory sprue. Only a few series of patients with well-characterized
refractory sprue have been reported in the literature. The prognosis is poor, though some patients respond to corticosteroids
and immunosuppressive agents. The presence of an aberrant clonal intraepithelial T-cell population has led to the designation
of refractory sprue as a cryptic intestinal T-cell lymphoma. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|