3.0T MR扩散加权成像评估前列腺癌分期、分级的价值

目的：探讨磁共振扩散加权成像（DWI）评估前列腺癌分期的价值，以及表观扩散系数（ADC）值与病理分级的相关性。材料与方法：使用Philips Achieva 3.0T高场强超导型磁共振和腹部多通道相控阵线圈，对46例前列腺癌患者行DWI检查，并测量ADC值。结果：对前列腺癌分期的诊断准确性，T2WI组为80%，DWI组为83%，DWI＋T2WI组为89%，各组AZ值分别为0.82、0.83和0.91，DWI+T2WI组明显高于其它组（P=0.02、0.04）。ADC均值：G1组为1.31×103mm，G2组为1.14×103mm，G3组为0.7×103mm，G3组平均ADC值低于G1和G2组（P<0.05）。结论：3.0T高场强DWI联合T2WI成像，可明显提高前列腺癌分期的准确性，ADC值能够预测肿瘤的病理分级。

Accuracy of 3.0T diffusion-weighted MRI for diagnosing the stage and grade of prostate cancer

Objective： To evaluate the ability of DWI in determining the stage of prostate cancer （PCA）, and to measure the correlation between apparent diffusion coefficient （ADC） with histologic grade. Materials and Methods： Forty-six patients underwent DWI with a 3.0T MR scanner using a pelvic array multi-coil. The ADC values of PCA were calculated. Results： The overall accuracy of T stage diagnosis was 80% for T2WI alone, 83% for DWI alone, 89% for T2WI plus DWI. The AZ value was significantly higher（P=0.02, 0.04） for DWI plus T2WI（AZ=0.91） than for T2WI alone（AZ=0.82） and for DWI alone（AZ= 0.83）. The mean ADC of G1 tumors was 1.31×10^3mm, 1.14×10^3mm for G2, 0.7×10^3mm for G3, The mean ADC of G3 tumors was lower than that of G1 and G2 tumors （P〈0.05）. Conclusion： Combined T2WI and DWI is better than DWI alone and T2WI alone in the accuracy of T stage diagnosis. The ADC value may predict the histologic grade of PCA.