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溃疡性结肠炎瘀血状态的试验研究
引用本文:陈亮,闫成秋. 溃疡性结肠炎瘀血状态的试验研究[J]. 中国肛肠病杂志, 2010, 0(11): 16-18
作者姓名:陈亮  闫成秋
作者单位:长春中医药大学附属医院肛肠科,吉林长春130021
摘    要:为观察溃疡性结肠炎(UC)患者是否存在瘀血,以及瘀血与疾病的活动性关系,本试验从血小板活化的角度,检测了UC患者体内血小板活化的各项指标。结果UC患者的血小板计数(PLT)、血小板α颗粒膜蛋白-140(GMP-140)、血栓素B2(TXB2)均高于正常人,血小板平均容积(MPV)低于正常人;同时Uc患者的PLT、GMP-140、TXB2与疾病的活动性分别呈正相关,MPV与疾病的活动性呈负相关。结果表明,UC发病过程中存在瘀血,并且瘀血与疾病的活动性密切相关。本试验进一步认识了UC的发病机制,不但为判断UC是否存在瘀血提供了有力的实验室依据,而且也为衡量中医药治疗UC的疗效提供了可靠标准,更加拓宽了中医药治疗UC的思路。

关 键 词:溃疡性结肠炎  瘀血  血小板活化

The Trial Study on the Blood Stasis Status in Ulcerative Colitis Patients
CHEN Liang,YAN Cheng-qiu. The Trial Study on the Blood Stasis Status in Ulcerative Colitis Patients[J]. , 2010, 0(11): 16-18
Authors:CHEN Liang  YAN Cheng-qiu
Affiliation:(Dept. of Coloproctology , the Affiliated Hospital to Changchun TCM University ,Changchun,Jilin 130021)
Abstract:The objective of this trial study was to investigate whether ulcerative colitis(WC) patients has or not blood stasis,and the relation of blood stasis to the activity of UC condition. From the angle of platelet activation each indexes of platelet activation of UC patients were detected in this trial. As results, in plate- let count(PLT),GMP-140,thromboxane(TX)B2 UC patients were higher than normal persons, but mean platelet volume(MPV) was lower than normal persons; in UC patients, PLT, GMP-140, TXB2 were related with the activity of disease condition positively, while MPV was related negatively. Results show that during UC invasion there was blood stasis, and the blood stasis was related with activity of dis- ease condition; through this study the pathogenesis mechanism of UC was understanded further, not only the strong laboratory evidence is provided for judging whether UC has or not blood stasis, but a feasible standard is also done for evaluating the curative effect of TCM in the treatment of UC. Develop idea for UC of TCM.
Keywords:Ulcerative colitis  Blood stasis  Platelet activation
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