我院抗生素使用现状调查及分析

目的了解我院抗菌药物的临床应用现状及存在问题。方法随机抽取我院2003年1215份出院病历进行回顾性调查。结果抗生素总使用率88．8％，预防用药使用率67．1％，治疗用药使用率77．6％。治疗用药中联合用药的比例为45.4％，抗生素使用频率最高的依次为青霉素(29．13％)、头孢拉啶(14．67％)、头孢噻肟钠(12．51％)、庆大霉素(9．20%)、甲硝唑(8．1％)、氨苄西林(7．41％)、环丙沙星(5．21％)等。大肠埃希菌对环丙沙星的耐药性达91．5％，肺炎克雷伯菌对氨苄西林的耐药性为80％，表皮葡萄球菌对环丙沙星、庆大霉素及青霉素多重耐药。结论我院抗菌药物使用率高，且存在较多不合理现象，应对我院抗菌药物的应用制定指导性政策。

Investigation and analysis of present status of antibiotics use

Objective To investigate the present status of antibiotics use in Panzhihua hospital of Intergrated Tradition Chinese Medicine and Western Medicine. Methods One thousand, two hundred and fifteen discharge cases were randomly selected for a retrospective investigation. Results The antibiotic use rate was 88.8%, 67.1% for prophylaxis, 77.6% for treatment, 45.4% for combined treatment, respectively. Frequ-ency of antibiotics use were as followes: penicillin (29.13%), cefradine (14.67%), cefotaxime (12.51%), gentamicin (9.20%), metronidazole (8.1%), ampicillin (7.41%), and ciprofloxacin (5.21%). Drug resistant rate of E.coli to ciprofloxacin were 91.5%, Klebsiella pneumoniae to ampicillin were 80%, S.epidermidis showed multiple drug resistance to ciprofloxacin, gentamicin and penicillin. Conclusion Antibiotics use rate is high. Instruction for rational use of antibiotics is necessary.