Inhibitory effects of miRNA-200c on chemotherapy-resistance and cell proliferation of gastric cancer SGC7901/DDP cells |
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| Authors: | Chen Yong Zuo Jing Liu Ying Gao Hong Liu Wei |
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| Affiliation: | Yong Chen,Jing Zuo,Ying Liu,Hong Gao,Wei Liu Department of Medical Oncology,Hebei Medical University,Shijiazhuang,Hebei 050011,P. R. China |
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| Abstract: | Background and Objective: miRNA-200c can not only inhibit the aggressiveness of cancer cells but also increase the sensitivity of cells to antitumor drugs. However, some mechanisms are still unclear. Recent researches revealed that E-cadherin is more than an inhibitor of metastasis, and it also plays important roles in reversing drug resistance. We had previously found that miRNA-200c could not only induce the expression of E-cadherin but also increase the sensitivity of gastric cancer SGC7901/DDP cells to ... |
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| Keywords: | miRNA-200c proliferation drug-resistance Bax Bcl-2 E-cadherin |
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