心房颤动患者华法林假日疗法的临床观察

目的：观察华法林假日疗法对心房颤动患者抗凝治疗的疗效及安全性。方法：将江苏省镇江市中医院2009年1月-2013年9月间收治的38例心房颤动患者随机分为华法林常规治疗组（对照组，n=20）和华法林假日疗法治疗组（观察组，n=18），观察两组患者为期12个月的不良反应发生情况。结果：观察组患者治疗后的脑血栓等栓塞事件的发生率与对照组患者间无显著差异（5.6%：5%，P＆gt;0.05）。观察组患者治疗后出血发生率低于对照组患者（5.6%：20%，P＜0.05），对照组由于未监测INR发生1例出血性死亡事件。结论：观察组患者栓塞风险未增加，出血风险发生率较低，价格便宜且不需要频繁监测INR，值得临床进一步观察使用。

Clinical observation on warfarin holiday-therapy in the treatment of patients with atrial fibrillation

Objective：To observe the efifcacy and safety of warfarin holiday-therapy on the anticoagulation in patients with atrial ifbrillation （AF）. Methods：Thirty-eight cases of patients with AF were randomly divided into two groups, a control group （conventional treatment of warfarin, n=20） and an observation group （warfarin holiday-therapy, n=18）, to observe the adverse reactions in two groups during 12 months. Results：There was no signiifcant difference in the incidence rate of embolism events such as cerebral thrombosis between two groups （5.6% vs 5%, P＆gt;0.05）, however, the incidence rate of bleeding was lower in the observation group than in the control group （5.6%vs 20%, P＆lt;0.05）. One case of hemorrhagic death occurred in the control group due to the absence of the monitoring of INR. Conclusion：Warfarin holiday-therapy is worthy of further clinical observation due to no risk of embolism increase, lower bleeding risk , inexpensive costs and no need of frequent monitoring and determination of INR.