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| 连接蛋白43在鼻咽癌组织细胞中的表达 | |
| 引用本文： | 沈志忠,林珏龙,李曼红,曾庆纯.连接蛋白43在鼻咽癌组织细胞中的表达[J].临床耳鼻咽喉头颈外科杂志,2002,16(8):402-403. |
| 作者姓名： | 沈志忠 林珏龙 李曼红 曾庆纯 |
| 作者单位： | 1. 汕头大学医学院第一附属医院耳鼻咽喉科,广东汕头,515041 2. 汕头大学医学院中心实验室,广东汕头,515041 3. 汕头大学医学院第一附属医院病理科,广东汕头,515041 |
| 摘 要： | 目的 :探讨连接蛋白 4 3(Connextion ,Cx4 3)的表达与鼻咽癌组织细胞的相关性。方法 :采用激光扫描共聚焦显微镜和荧光技术 ,对 18例鼻咽癌和 10例鼻咽慢性炎症组织细胞中 ,Cx4 3的表达进行形态观察和定量分析。结果 :Cx4 3在鼻咽癌组织细胞膜中的表达显著低于鼻咽慢性炎症组织 ,两组细胞膜的Cx4 3荧光值之间差异具有非常显著性意义 (P <0 .0 1)。结论 :Cx4 3的表达水平与鼻咽癌的发生和发展有关 ,细胞间隙连接通讯减弱或缺失是鼻咽癌形成及恶性转变的重要因素之一。 |
| 关 键 词： | 鼻咽肿瘤 细胞间接合 连接蛋白43 |
| 文章编号： | 1001-1781(2002)08-0402-03 |
| 修稿时间： | 2001年12月19 |
Study on the expression of connexin 43 in human nasopharyngeal carcinoma |
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| SHEN Zhizhong,LIN Juelong,LI Manhong,ZENG Qingchun.Study on the expression of connexin 43 in human nasopharyngeal carcinoma[J].Journal of Clinical Otorhinolaryngology,2002,16(8):402-403. | |
| Authors: | SHEN Zhizhong LIN Juelong LI Manhong ZENG Qingchun |
| Institution: | Department of Otolaryngology, First Affiliated Hospital of Shantou University Medical College, Shantou 515041. |
| Abstract: | OBJECTIVE: To study the relationship of the expression of connexin 43 (Cx43) in human nasopharyngeal carcinoma (NPC). METHOD: The cell shape and the expression of Cx43 in 18 cases of NPC and 10 cases of chronic inflammation disease of nasopharyngeal epitheliems (CIDNE) were observed under the laser scanning confocal microscopy and technology of fluorescence. RESULT: The scanning images displayed that the fluorescence signal of Cx43 in cell membrane of NPC was significantly lower than in CIDNE (P < 0.01). CONCLUSION: The expression of Cx43 plays an important role in the development of NPC. The reduced or loss of gap junctional intercellular communication may be one of the important factors in the development of a normal nasopharyngeal epithelium cell into a neoplastic one. |
| Keywords: | Nasopharyngeal neoplasms Intercellular junctions Connexin 43 |
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