麝香"归经入脑"的实验研究

目的:研究中药麝香透过血脑屏障对中枢的作用途径.方法:用麝香的主要有效成分麝香酮,经大鼠尾静脉注射,按不同时间取其脑等内脏,制备组织样品,用气相色谱法测定其透过血脑屏障的脑内分布和其他脏器分布.结果:麝香酮可通过正常大鼠的血脑屏障分布于脑组织内,且很快达到高峰,具有相当浓度,而代谢较其他脏器缓慢.结论:麝香可以"归经入脑",色谱法是研究中药有效成分通过血脑屏障的可取方法.

An experimental study on distribution of musk into the brain through blood brain barrier

Objective:To study the possible pathway of the effect of musk on brain disorder,distributing into the brain through blood brain barrier.Methods:We used the musk ketone (muscone), a main composition of musk,to inject through the tail vein of the rats into the blood and took the brain and other organs at different times to make samples. Then gas chromatography was used to measure the distribution of muscone in the brain and other organs.Results:Muscone could pass through the normal rat's blood brain barrier into the brain and soon reached the highest peak and remained in higher concentration, and more slowly metabolized as compared with other organs.Conclusion:Musk distributing into the brain through blood brain barrier provides the basis for its effect in treating brain disorders. Chromatography is an effective method to study the active composition of Chinese herbal medicine distributing through the blood brain barrier into the brain.