The differential effect of lithium on noradrenaline- and dopamine-sensitive accumulation of cyclic AMP in guinea pig brain |
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| Authors: | A. Reches R. P. Ebstein R. H. Belmaker |
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| Affiliation: | (1) The Jerusalem Mental Health Center-Ezrath Nashim, P.O.B. 140, Jerusalem, Israel |
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| Abstract: | Lithium (Li) in its narrow therapeutic concentration range was found to inhibit only the noradrenaline- and not the dopamine-sensitive accumulation of cyclic AMP in guinea pig brain. The results suggest a pharmacological distinction between the antischizophrenic drugs that inhibit dopamine-sensitive cyclic AMP accumulation and Li, an antimanic agent that inhibits specifically only the noradrenalinesensitive cyclic AMP accumulation. |
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| Keywords: | Lithium Noradrenaline- and dopaminesensitive cyclic AMP accumulation Differential inhibition Guinea pig brain |
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