粪便钙卫蛋白在新生儿期的临床研究进展

新生儿胃肠功能异常与生后生长发育落后密切相关,寻找能反映胃肠功能的早期特异性指标有助于指导合理的肠道喂养,预测评价胃肠道疾病的发生.钙卫蛋白是一种主要来源于中性粒细胞的钙-锌结合蛋白质,是急性炎性细胞活化的标志物.有研究表明新生儿期粪便钙卫蛋白呈高水平表达,肠道损伤时粪便钙卫蛋白含量明显升高,并可作为检测胃肠道疾病（如喂养不耐受、新生儿腹泻、坏死性小肠结肠炎等）的发生,评价肠道疾病严重程度的无创性指标.该文就新生儿期粪便钙卫蛋白水平的变化及临床意义作一综述.

Clinical research advancement of fecal calprotectin during the neonatal period

Neonatal gastrointestinal dysfunction was closely related to postnatal growth retardation.Looking for an early specific indicator to reflect gastrointestinal function was important.Calprotectin was a calciumzinc binding protein mainly in human neutrophil granulocytes,which was the marker of acute inflammatory cell activation.Fecal calprotectin was expressed at high levels during the neonatal period and was significantly higher in the intestinal damage,which could be used as the marker of intestinal illnesses （such as feeding intolerance,neonatal diarrhea,necrotizing enterocolitis）.This review will summarize the characteristics of fecal calprotectin in neonates and its clinical significance as a noninvasive marker of intestinal illnesses during the neonatal period.