结核杆菌初始耐药对化疗效果的影响

目的 了解结核杆菌初始耐药对化疗的影响。方法将我院2001年1月-2005年12月4年间未用过抗结核药或用药未超过1月、有药物敏感性测定、门诊随访记录资料完整的肺结核患者分为耐药组(134例)及敏感组(162例),进行对比分析。结果痰菌阴转率前者为77.6%、后者为96.9%,2年细菌学复发率10.8%及3.5%。耐1药者痰菌阴转率89.1%;耐2药及3药者各为72.7%及54.5%。结论初始耐药,尤其耐多药是化疗失败的主要原因。

Effect of initial Drug Resistance of Mycobacterium Tuberculosis on the Chemotheraty of Tuberculosis

Objective To investigate the effect of mycobacterium tuberculosis initial resistance on the chemotheraty of pulmonary tuberculosis.Methods The patients of mycobacterium tuberculosis,treatde without durgs or with those drugs but not beyond one month,and with drug sensibilities test,follow-up,and completely recordedf data in out-patient dipartment in 4 years from January 2001 to Decenber 2005 in our hospital,were divided into two groups:drug rsesitant group(134 casis) and drug-sensitive group(162 cases).Two groups were compared.Results The sputum culture conversion rate of the former was 77.6%,the rate of the latter was 96.9%.The bacteriological relapse rate of converted cases during 2 year follow-up was 10.8%,3.5% respectively,The sputum culture conversion rate of one drug resistance was 89.1%,the rate of two drugs resistance was 72.7%,and the rate of three drugs resistance was 54.5%.Conclusion The initial drug resistance,especially multiple drug resistance was the main reason of the chemogherapy failure. Mycobacterium;Drug resistance;Tuberculosis