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Validation of the Stage Groupings in the Eighth Edition of the TNM Classification for Lung Cancer |
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| Affiliation: | 1. Department of Thoracic Surgery, Center for Mini-invasive Thoracic Surgery, People’s Hospital, Peking University, No. 11, Xizhimen South Street, Xicheng District, Beijing 100044, People''s Republic of China;2. Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, No. 180, Fenglin Road, Xuhui District, Shanghai 200032, People''s Republic of China |
| Abstract: | IntroductionThe aim of this study was to validate stage groupings in the eighth edition of the TNM classification in an independent Chinese cohort.MethodsWe retrospectively analyzed a total of 3599 patients with pathological stage IA to IIIA (seventh edition of the TNM) NSCLC who underwent surgical treatment in two surgical centers in the People's Republic of China between 2005 and 2012. All patients were reclassified according to the eighth edition of the TNM classification. Survival was compared between adjacent stage groupings by using a log-rank test and a Cox regression model. R2 was calculated to evaluate the discrimination of the two TNM stage classifications.ResultsThe median follow-up time was 48.7 months. According to the eighth edition of the TNM classification, the overall survival (OS) of adjacent stage groupings showed significant differences except for IA3 vs. IB. The eighth edition of the TNM classification yielded a slightly higher R2 than the seventh edition (0.172 vs. 0.162).ConclusionsThis study provided an external validation of the stage groupings in the eighth edition of the TNM classification for lung cancer among surgically treated Chinese patients with NSCLC. |
| Keywords: | TNM classification Non–small cell lung cancer External validation Thoracic surgery |
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