Long-term outcomes of pediatric inflammatory bowel disease |
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| Affiliation: | 1. Division of Gastroenterology, Hepatology and Nutrition, CHEO Inflammatory Bowel Disease Centre, Children’s Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, Canada K1H 8L1;2. Children’s Hospital of Eastern Ontario (CHEO) Research Institute, Ottawa, Canada;3. Institute for Clinical Evaluative Sciences, Ottawa, Canada;4. Department of Pediatrics and School of Epidemiology and Public Health, University of Ottawa, Ottawa, Canada;1. Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children’s Medical Center, Israel;2. Sackler Faculty of Medicine, Tel-Aviv University, Israel;1. Division of Pediatric Gastroenterology, Emory University School of Medicine, Atlanta, GA, USA;2. Children''s Healthcare of Atlanta, Atlanta, GA, USA;3. Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children''s Hospital Medical Center, Cincinnati, OH, USA;4. Division of Biostatistics and Epidemiology, Cincinnati Children''s Hospital Medical Center, Cincinnati, OH, USA;5. Division of Pulmonary Biology, Cincinnati Children''s Hospital Medical Center, Cincinnati, OH, USA;6. Division of Biomedical Informatics, Cincinnati Children''s Hospital Medical Center, Cincinnati, OH, USA;7. Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada;8. Center for Integrative Genomics, Georgia Institute of Technology, Atlanta, GA, USA;9. The Broad Institute of MIT and Harvard, Cambridge, MA, USA;10. Department of Biostatistics, Harvard T H Chan School of Public Health, Boston, MA, USA;11. Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Medical College of Wisconsin, Milwaukee, WI, USA;12. Department of Pediatric Gastroenterology, Nationwide Children''s Hospital, Ohio State University College of Medicine, Columbus, OH, USA;13. Department of Gastroenterology and Nutrition, Boston Children''s Hospital, Boston, MA, USA;14. Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, USA;15. Department of Pediatrics, Goryeb Children''s Hospital, Morristown, NJ, USA;p. Department of Pediatrics, Hasbro Children''s Hospital, Providence, RI, USA;q. Department of Pediatrics, University of Utah, Salt Lake City, UT, USA;r. Department of Pediatrics, Children''s Hospital of Eastern Ontario IBD Centre and University of Ottawa, ON, Canada;s. Section of Pediatric Gastroenterology, Baylor College of Medicine, Texas Children''s Hospital, Houston, TX, USA;t. Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA;u. Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA;v. Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA;w. Department of Gastroenterology, Children''s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA;x. Children''s Center for Digestive Health Care, Atlanta, GA, USA;y. Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA;z. Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA;11. Department of Pediatrics, Dalhousie University, Halifax, NS, Canada;12. Department of Digestive Diseases and Nutrition Center, University at Buffalo, Buffalo, NY, USA;13. Department of Pediatrics, Nemours Children''s Specialty Care, Jacksonville, FL, USA;14. Department of Pediatrics, University of Chicago, Chicago, IL, USA;15. Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA;16. Department of Pediatrics, UCLA David Geffen School of Medicine, Los Angeles, CA, USA;17. Department of Pediatric Gastroenterology, Mayo Clinic, Rochester, MN, USA;18. Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA;19. Department of Pediatrics, Northwell Health, New York, NY, USA;110. Department of Pediatrics, Mount Sinai Hospital, New York, NY, USA;111. Center for Computational and Integrative Biology, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA, USA;112. Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, USA;113. Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children''s Medical Center, Hartford, CT, USA;1. Children’s Hospital of Eastern Ontario Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, Children’s Hospital of Eastern Ontario, Ottawa, Canada;2. Department of Pediatrics, University of Ottawa, Ottawa, Canada;3. Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Canada;4. Institute for Clinical Evaluative Sciences, Toronto, Canada;5. Department of Medicine, University of Toronto, Toronto, Canada;6. Department of Paediatrics, University of Toronto, Toronto, Canada;7. Mount Sinai Centre for Inflammatory Bowel Disease, Toronto, Canada;8. Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children’s Hospital Boston, Boston, Massachusetts;9. Department of Medicine, Harvard University, Boston, Massachusetts;10. SickKids Inflammatory Bowel Disease Center, Division of Gastroenterology Hepatology and Nutrition, Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada;1. Inflammatory Bowel Disease Center, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire;3. Biomedical Libraries, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire;4. Pediatric Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California;1. Division of Gastroenterology, Hepatology and Nutrition, The Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA;2. Pediatric Gastroenterology, Clinical Development and Research Affairs, Goryeb Children''s Hospital/Atlantic Health, Icahn School of Medicine at Mount Sinai, 100 Madison Avenue, Morristown, NJ 07962, USA |
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| Abstract: | The incidence and prevalence of childhood-onset inflammatory bowel diseases (IBD), including subtypes Crohn's disease and ulcerative colitis, have risen dramatically in recent years, and have emerged globally as important pediatric chronic diseases. Therefore, health care providers are more frequently encountering very young children with IBD, a chronic and incurable condition requiring life-long therapy. These children are living long lives with IBD and therefore knowledge of long-term outcomes is increasingly important to better counsel families and determine the best course of treatment. This review summarizes the current knowledge and literature surrounding long-term outcomes of pediatric IBD, with emphasis on the following areas: need for surgery due to complicated disease behavior, risk of disease remission and recurrence, mental health and psychosocial well-being, educational outcomes, linear growth impairment, cancer risk, and mortality. In addition, we review recent research about predicting negative long-term outcomes in children with IBD. |
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| Keywords: | Inflammatory bowel diseases Pediatric Outcomes Surgery Complications Epidemiology |
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