| 调节自噬治疗多发性骨髓瘤的研究进展 |
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| 引用本文： | 杨炳钦,陈君敏,曾志勇.调节自噬治疗多发性骨髓瘤的研究进展[J].中国实验血液学杂志,2020(2):700-703. |
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| 作者姓名： | 杨炳钦 陈君敏 曾志勇 |
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| 作者单位： | 福建医科大学第一临床医学院 |
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| 基金项目： | 国家自然科学基金(81400160、81272628);福建省自然科学基金(2017J01185);福建省高校杰出青年科研人才计划(2016B027);福建省中青年教师教育科研项目(NO.JT180185)。 |
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| 摘 要： | 自噬是真核生物中细胞对异常蛋白质、细胞器降解的过程,其对正常的细胞与肿瘤细胞的生存都有重要影响。研究表明,自噬广泛存在于骨髓瘤细胞的生命活动中,其不仅能保护骨髓瘤细胞,也能诱导其死亡,对骨髓瘤细胞的生存、增殖、侵袭与迁移以及多发性骨髓瘤的治疗起着重要的作用。本文就调节自噬水平在治疗多发性骨髓瘤中的研究进展作一综述。
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| 关 键 词： | 自噬 多发性骨髓瘤 治疗 |
Research Progress on Regulating Autophagy in the Treatment of Multiple Myeloma--Review |
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| YANG Bing-Qin,CHEN Jun-Min,ZENG Zhi-Yong.Research Progress on Regulating Autophagy in the Treatment of Multiple Myeloma--Review[J].Journal of Experimental Hematology,2020(2):700-703. |
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| Authors: | YANG Bing-Qin CHEN Jun-Min ZENG Zhi-Yong |
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| Institution: | (First Clinical Medical College of Fujian Medical University,Department of Hematology and Rheumatology,The First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,Fujian Province,China) |
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| Abstract: | Autophagy is a process in which cells in eukaryotes degrades abnormal proteins and organelles,thus it possesses important effects on the survival of normal cells and tumor cells.The related studies have shown that autophagy is widely present in the life activities of myeloma cells,which not only protects myeloma cells,but also induces death,and plays an important role in survival,proliferation,invasion and migration of myeloma cells and the treatment of multiple myeloma.This review focuses on the progress of regulating autophagy in the treatment of multiple myeloma. |
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| Keywords: | autophagy multiple myeloma treatment |
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