Interpregnancy weight change and adverse maternal outcomes: a retrospective cohort study |
| |
| Affiliation: | 1. Department of Epidemiological Methods and Etiologic Research, Leibniz Institute for Prevention Research and Epidemiology — BIPS, Achterstr. 30, 28359 Bremen, Germany;2. Department of Biometry and Data Management, Leibniz Institute for Prevention Research and Epidemiology — BIPS, Achterstr. 30, 28359 Bremen, Germany;3. Research Centre in Epidemiology and Preventive Medicine — EPIMED, Department of Clinical and Experimental Medicine, University of Insubria, Via O Rossi 9, 21100 Varese, Italy;4. Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Via dell''Elettronica, 86077 Pozzilli, Italy;5. Department of Chronic Diseases, Centre of Behavioural and Health Sciences, National Institute for Health Development, Hiiu St 42, 11619 Tallinn, Estonia;6. Department of Public Health and Community Medicine, University of Gothenburg, Medicinaregatan 16, 40530 Gothenburg, Sweden;7. Department of Paediatrics, Queen Silvia Children''s Hospital, University of Gothenburg, Rondvägen 10, SE 41686 Gothenburg, Sweden;8. Department of Pediatrics, University of Pécs, József A. u. 7, 7623 Pécs, Hungary;9. GENUD (Growth, Exercise, Nutrition and Development) Research Group, University School of Health Sciences, University of Zaragoza, C/Domingo Miral s/n, 50009 Zaragoza, Spain;10. Institute of Food Sciences, National Research Council, Via Roma 64, 83100 Avellino, Italy;11. Department of Public Health, Ghent University, UZ 2 Blok A De Pintelaan 185, 9000 Ghent, Belgium;12. Faculty of Mathematics and Computer Science, Bremen University, Bibliothekstr. 1, 28359 Bremen, Germany;1. Department of Pediatric Surgery and Orthopedics, Oulu University Hospital, Finland;2. PEDEGO Research Group, University of Oulu, Oulu, Finland;3. Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland;4. Primary Care Unit, Oulu University Hospital, Oulu, Finland;5. Center for Life Course Health Research, University of Oulu, Oulu, Finland |
| |
| Abstract: | PurposeExamine associations between interpregnancy body mass index (BMI) change (difference in the pre-pregnancy BMIs of two consecutive pregnancies) and gestational diabetes mellitus (GDM), pre-eclampsia (PE), gestational hypertension (GHtn), primary cesarean delivery, and vaginal birth after cesarean delivery (VBAC).MethodsModified Poisson regression models estimated adjusted associations.ResultsEvery 1-unit increase in interpregnancy BMI increased risks of GDM (relative risk [RR]: 1.09; 95% confidence interval [CI], 1.07–1.11), PE (RR: 1.06; 95% CI, 1.04–1.09), GHtn (RR: 1.08; 95% CI, 1.06–1.10), and primary cesarean delivery (RR: 1.03; 95% CI, 1.01–1.05) and decreased the risk of a successful VBAC (RR: 0.98; 95% CI: 0.97–0.997) in the second pregnancy. A BMI increase of ≥3 units increased risks of GDM (RR: 1.71, 95% CI, 1.52–1.93), PE (RR: 1.60, 95% CI, 1.33–1.94), GHtn (RR: 1.66, 95% CI, 1.42–1.94), and primary cesarean delivery (RR: 1.29, 95% CI, 1.12–1.49) and decreased the risk of a successful VBAC (RR: 0.89; 95% CI, 0.80–0.99) compared to women with interpregnancy BMI change within −1 and +1 unit. GDM was also increased among women increasing their BMI by ≥2 but <3 units (RR: 1.40; 95% CI, 1.21–1.61) and among those gaining ≥1 but <2 units (RR: 1.23; 95% CI, 1.08–1.40).ConclusionAn interpregnancy BMI increase of ≥3 units is associated with an increased risk of all outcomes. These findings emphasize the importance of interpregnancy weight management. |
| |
| Keywords: | Cesarean section Gestational diabetes Gestational hypertension Body mass index Pre-eclampsia Vaginal birth after cesarean |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
