First experiences with model based iterative reconstructions influence on quantitative plaque volume and intensity measurements in coronary computed tomography angiography |
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| Institution: | 1. Odense University Hospital Svendborg, Medical Research Department, Valdemarsgade 53, 5700 Svendborg, Denmark;2. Conrad Research Center, University College Lillebelt, Niels Bohrs Allé 1, 5230 Odense M, Denmark;3. Leiden University Medical Center, Department of Radiology, Division of Image Processing, Albinusdreef 2, 2300 RC Leiden, The Netherlands;4. Medis Medical Imaging Systems B.V, Schuttersveld 9, 2300 AJ Leiden, The Netherlands;5. Odense University Hospital, Department of Nuclear Medicine, Sdr. Boulevard 29, 5000 Odense C, Denmark;6. University of Southern Denmark, Centre of Health Economics Research, Campusvej 55, 5230 Odense M, Denmark;7. Århus University Hospital, Department of Clinical Engineering, Brendstrupgaardsvej 100, 8200 Århus N, Denmark;1. University of Salford, Salford M6 6PU, UK;2. Lisbon School of Health Technology, 1990-096 Lisbon, Portugal;3. Public Health Research Center, National School of Public Health, NOVA University of Lisbon, Portugal;4. Karolinska Institute, SE-171 77 Stockholm, Sweden |
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| Abstract: | PurposeInvestigate the influence of adaptive statistical iterative reconstruction (ASIR) and the model-based IR (Veo) reconstruction algorithm in coronary computed tomography angiography (CCTA) images on quantitative measurements in coronary arteries for plaque volumes and intensities.MethodsThree patients had three independent dose reduced CCTA performed and reconstructed with 30% ASIR (CTDIvol at 6.7 mGy), 60% ASIR (CTDIvol 4.3 mGy) and Veo (CTDIvol at 1.9 mGy). Coronary plaque analysis was performed for each measured CCTA volumes, plaque burden and intensities.ResultsPlaque volume and plaque burden show a decreasing tendency from ASIR to Veo as median volume for ASIR is 314 mm3 and 337 mm3–252 mm3 for Veo and plaque burden is 42% and 44% for ASIR to 39% for Veo. The lumen and vessel volume decrease slightly from 30% ASIR to 60% ASIR with 498 mm3–391 mm3 for lumen volume and vessel volume from 939 mm3 to 830 mm3. The intensities did not change overall between the different reconstructions for either lumen or plaque.ConclusionWe found a tendency of decreasing plaque volumes and plaque burden but no change in intensities with the use of low dose Veo CCTA (1.9 mGy) compared to dose reduced ASIR CCTA (6.7 mGy & 4.3 mGy), although more studies are warranted. |
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| Keywords: | Cardiac CT Iterative reconstructions MBIR Veo Plaque analysis Image quality |
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