Risk of second malignant neoplasms in women and girls with germ cell tumors |
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| Affiliation: | 1. Division of Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children’s Hospital, Boston;2. Interdepartmental Program in Biochemistry, Wellesley College, Wellesley, USA;3. Medical Science, Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, Brazil;4. Department of Pediatrics, Division of Epidemiology and Clinical Research;5. Departments of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis;6. Departments of Pediatrics;7. Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas;8. Center for Cancer and Blood Disorders, Children’s Medical Center, Dallas;9. Department of Global Pediatric Medicine, St. Jude Children’s Research Hospital, Memphis, USA |
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| Abstract: | BackgroundWhile an elevated risk of second malignant neoplasms (SMNs) has been observed in men treated for germ cell tumors (GCTs), risk of SMNs have not been quantified in adult women or in girls treated for GCTs.Patients and methodsOne-year survivors of primary GCTs diagnosed between January 1980 and December 2012 were identified from Surveillance, Epidemiology, and End Results (SEER 9) registries. Risk of SMNs was calculated using SEER*Stat.ResultsAmong 1507 patients, a total of 47 SMNs were identified. The overall risk of SMNs was not elevated in females overall or in females treated for GCT during adulthood although SMN sites (pancreas, soft tissue, bladder, kidney, and thyroid) and trends were comparable with those in men. There were too few childhood GCT cases with SMNs for further analysis.ConclusionsUnlike men, women treated for GCTs did not have a statistically significant elevated risk of SMNs [standardized incidence ratio = 1.11; 95% confidence interval (CI) = 0.81–1.47]. The fact that SMNs in women occur in sites similar to those observed in men indicate that long-term follow-up of a larger cohort of females treated for GCT is warranted. |
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