基于网络药理学的个体化治疗与药物组合设计

网络药理学通过解析分子网络中多种组分之间的相互关系来研究疾病条件下的特征性网络改变,并研究药物作用下该网络受到扰动的模式,从而实现网络层面上的药物作用机制研究。目前,网络药理学的基础理论研究仍处于起步阶段。本文以一些具有代表性的实例,初步阐述基于网络药理学原理进行药物组合理性设计和个体化治疗策略设计的原理与方法,讨论网络构建方面的创新空间及其在网络药理学中的应用潜力。遗传相互作用网络将在基于网络的药理学研究中发挥更大、更广泛的作用。

Principle of rational design of drug combination and personalized therapy based on network pharmacology

Network pharmacology attempts to model the effects of drug action by simultaneously modulating multiple components in a gene network. However, the theoretical basis for this new concept is still in its infancy. In this mini-review, we try to outline the principle of rational designs for drug combination and personalized therapy based on network pharmacology by deciphering several milestone examples. We also tentatively outlined several aspects of the process which might help drive innovation in network construction and shape the future development of network pharmacology applications.