Morphological evaluation of toxic effect of kartolin-2

Lipid dystrophy, rapid reduction of RNA and glycogen content in the liver of all experimental rats, developing as a result of acute kartolin-2 poisoning testify to an expressed hepatotropic effect of the substance. Alongside with the processes of parenchymal liver cell damage the signs of intracellular regenerating processes--increase of the size of hepatocytes nuclei are detected. Liver protein metabolism disturbances are observed following exposure to kartolin-2 in the acute experiment. Chronic exposure to kartolin-2, and, specifically to its preparation form in the dose 1/100 LD50 cause lipid infiltration, reduction of histochemical indicators of liver glycogen, and RNA content. No-effect doses of kartolin-2 have been determined.