初发2型糖尿病患者勃起功能障碍与同型半胱氨酸关系的初步探讨

目的 探讨初发2型糖尿病患者勃起功能障碍与血清同型半胱氨酸水平的关系,并分析影响勃起功能的其他因素.方法收集30例初发2型糖尿病合并勃起功能障碍患者[根据国际勃起功能指数(IIEF-5)评分判定],同时收集33例初发2型糖尿病未合并勃起功能障碍患者为对照组,并设正常对照组30例.用特定蛋白分析仪免疫散射比浊法测定血清总同型半胱氨酸,并测定血糖、HbA_(IC)、胰岛素、血脂、尿酸、性激素等指标.结果糖尿病勃起功能障碍组血清总同型半胱氨酸水平[(12.9±1.2)μmol/L]明显高于糖尿病非勃起功能障碍组[(9.9±1.6)μmol/L,P<0.05]及正常对照组[(7.2±1.1)μmol/L,P<0.01];初发2型糖尿病患者IIEF-5评分与总同型半胱氨酸、年龄、吸烟、体重指数、HbA_(IC)、空腹血糖负相关(相关系数分别为-0.574、-0.413、-0.231、-0.242、-0.274、-0.371,P<0.05或P<0.01),与高密度脂蛋白胆固醇呈正相关(相关系数为0.275,P=0.013).结论糖尿病勃起功能障碍是一个多环节、多病因参与的结果,同型半胱氨酸可能是糖尿病性勃起功能障碍一个新的危险因素.

Correlation between erectile dysfunction and serum homocysteine level in type 2 diabetic patients

Objective To detect the relationship between serum homocysteine(Hcy)level and erectile dysfunction in type 2 diabetic patients,and to investigate the factors which influence the erectile function.Methods Thirty type 2 diabetic patients with erectile dysfunction were recruited as the first group in the study.32type 2 diabetic patients without erectile dysfunction were included as the second group.30 healthv subjects served as control.Serum total Hcy was measured by protein-specific immune analyzer nephelometry in all subjects.Fasting and postprandial plasma glucose,HbA_(IC),fasting insulin,blood lipids,uric acid,sex hormones,and other biochemical indicators were measured in all participants.Results The serum total Hcy level in the group with erectile dysfunction[(12.9±1.2)μmol/L]was significantly higher than that in both of the group without erectile dysfunction[(9.9±1.6)μmol/L,P<0.05]and the control group[(7.2±1.1)μmol/L,P<0.01].International index of erectile function(IIEF)-5 score in patients with type 2 diabetes was negatively correlated with serum levels of total Hcy,age,smoking history,body mass index,HbAIC,and fasting plasma glucose(r were-0.574,-0.413,-0.231,-0.242,-0.274,-0.371,respectively,P<0.05 or P<0.01).and significantly positive correlation existed between IIEF-5 scores and high-density lipoprotein-cholesterol(r=0.275.P=0.013).Conclusions Erectile dysfunction in diabetic patients is a consequence caused by multi-factors with a complicatcd mechanism.Hcy seems to be a possible risk factor in diabetic patients with erectile dysfunction.