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| 肝郁证、脾虚证、肝郁脾虚证下丘脑、蓝斑CRF含量变化研究 | |
| 引用本文： | 蔡淦,张玉喜,刘群,雷云霞,丛军,张正利.肝郁证、脾虚证、肝郁脾虚证下丘脑、蓝斑CRF含量变化研究[J].上海中医药杂志,2006,40(8):1-3. |
| 作者姓名： | 蔡淦 张玉喜 刘群 雷云霞 丛军 张正利 |
| 作者单位： | 1. 上海中医药大学附属曙光医院消化科,上海,200021 2. 宁夏医学院附属医院传染科,宁夏,银川,750004 3. 第二军医大学附属长海医院消化科,上海,200433 |
| 基金项目： | 国家自然基金资助项目(30171124) |
| 摘 要： | 目的探讨肝郁脾虚证、脾虚证、肝郁证与神经肽CRF之间的相关性。方法用足电刺激、大黄灌胃、电刺激 大黄灌胃方法分别复制肝郁证、脾虚证、肝郁脾虚证大鼠模型,用放射免疫方法测定各组实验大鼠下丘脑和蓝斑CRF含量。结果肝郁组下丘脑CRF含量降低,脾虚组下丘脑CRF含量存在升高趋势,二者之间有显著性差异(P<0.05);肝郁组蓝斑CRF含量明显升高,与正常组、脾虚组、肝郁脾虚组比较均有显著性差异(P<0.05)。结论肝郁组下丘脑CRF降低,脾虚组CRF在下丘脑存在升高趋势;肝郁组蓝斑CRF明显升高。下丘脑CRF在肝郁组和脾虚组之间的差异,可能是肝郁证和脾虚证的中枢差异点之一;肝郁组蓝斑CRF升高,可能是肝郁证证本质的核心点。 |
| 关 键 词： | 肝郁证 脾虚证 肝郁脾虚证 下丘脑 蓝斑 CRF |
| 文章编号： | 1007-1334（2006）08-0001-03 |
| 收稿时间： | 2006-01-21 |
| 修稿时间： | 2006年1月21日 |
Contents of Corticotropin Releasing Factor in Hypothalamus and Locus Ceruleus in Rats with Liver-Depression Syndrome, Spleen-Deficiency Syndrome and Liver-Depression and Spleen-Deficiency Syndrome |
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| CAI Gan,ZHANG Yu-xi,LIU Qun,LEI Yun-xia,CONG Jun,ZHANG Zheng-li.Contents of Corticotropin Releasing Factor in Hypothalamus and Locus Ceruleus in Rats with Liver-Depression Syndrome, Spleen-Deficiency Syndrome and Liver-Depression and Spleen-Deficiency Syndrome[J].Shanghai Journal of Traditional Chinese Medicine,2006,40(8):1-3. | |
| Authors: | CAI Gan ZHANG Yu-xi LIU Qun LEI Yun-xia CONG Jun ZHANG Zheng-li |
| Institution: | CAI Gan1 ZHANG Yu-xi2 LIU Qun3 LEI Yun-xia1 CONG Jun1 ZHANG Zheng-li1 1. Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine; 2. Affiliated Hospital of Ningxia Medicl School; 3. Changhai Hospital Affiliated to Second Military Medical University |
| Abstract: | Objective To study the correlativity between liver-depression and spleen-deficiency syndrome, spleen-deficiency syndrome, liver-depression syndrome and corticotrophin releasing factor(CRF). Methods Corresponding rat models were established by electro-acupuncture and gastric perfusion of Rhubarb. Radioimmunoassay was adopted to detect the contents of CRF in hypothalamus and locus ceruleus. Results CRF in hypothalamus fell in liver-depression rats, while it rose in spleen-deficiency syndrome, P < 0.05; CRF in locus ceruleus rose in liver-depression syndrome, with a significant difference in comparison with other syndromes, P < 0.05. Conclusion CRF may be the core of the essence of liver-depression syndrome. |
| Keywords: | Liver-depression syndrome spleen-deficiency syndrome liver-depression and spleen-deficiency syndrome hypothalamus locus ceruleus corticotrophin releasing factor(CRF) |
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