Immunologic changes in obesity |
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Authors: | Craft Mitchell K Reed Mary Jane |
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Affiliation: | Division of Critical Care Medicine, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA 17822, USA. |
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Abstract: | A growing body of literature suggests multifaceted alterations to the immune function in obese patients compared with a lean cohort. Although treatment in the intensive care unit has an associated risk of infectious complications, which, if any, of these immunologic alterations are causal is unclear. Obesity clearly causes abundant alterations to the immune system. Overall, the aggregate effect seems to be chronic activation of inflammatory mediators. |
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Keywords: | Obesity Leptin Adiponectin Adipocytes Macrophage |
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