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Clinical management of salivary gland hypofunction and xerostomia in head-and-neck cancer patients: successes and barriers |
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| Authors: | Vissink Arjan Mitchell James B Baum Bruce J Limesand Kirsten H Jensen Siri Beier Fox Philip C Elting Linda S Langendijk Johannes A Coppes Robert P Reyland Mary E |
| Institution: | Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Grongingen, The Netherlands. |
| Abstract: | The most significant long-term complication of radiotherapy in the head-and-neck region is hyposalivation and its related complaints, particularily xerostomia. This review addresses the pathophysiology underlying irradiation damage to salivary gland tissue, the consequences of radiation injury, and issues contributing to the clinical management of salivary gland hypofunction and xerostomia. These include ways to (1) prevent or minimize radiation injury of salivary gland tissue, (2) manage radiation-induced hyposalivation and xerostomia, and (3) restore the function of salivary gland tissue damaged by radiotherapy. |
| Keywords: | Radiotherapy Hyposalivation Xerostomia Prevention Palliative care Gene transfer Stem cell therapy |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |